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. 2017 Mar 24;5:21. doi: 10.3389/fcell.2017.00021

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Copyright © 2017 Gálvez, Abelló and Giraldez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specification of neurons and hair cells during inner ear development. The three cell types that constitute the functional unit of the sensory patches of the inner ear are: neurons (blue), supporting cells (SC, pink) and hair cells (HC, red). The three cell types derive from the neurosensory epithelium that is specified by Sox2 and Sox3 after FGF signaling. Upon neurosensory induction, HC differentiation is delayed with respect to neurons. Neurog1 is expressed in neuronal precursors and after neurogenesis Atoh1 is expressed in the prospective hair cells. Notch signaling contributes to cell determination in two rounds of lateral inhibition, first to single out neuronal precursors (neurogenesis) and, secondly, to decide between hair cells and supporting cells (sensorigenesis).