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. 2017 Mar 24;5:21. doi: 10.3389/fcell.2017.00021

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Copyright © 2017 Gálvez, Abelló and Giraldez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hey1 prevents HC formation in ovo. (A) E3.5 chicken embryos were electroporated with Hey1 (left image) or EGFP-C1 (right image) and then sectioned after 3 days of incubation (E3.5+3). Electroporated cells in the macula sacularis were found mainly in the SC layer, and very few developed as HCs. Control electroporation with EGFP-C1 (E3.5+3) is shown on the right. (B) Hey1 electroporation biased electroporated cells toward supporting cell fate. The fraction of HCs that were electroporated (8%) was smaller than that of SCs (28%), similar to the efficiency of the electroporation (24%). Bars represent the number of cells counted in two consecutive frames of electroporated macula sacularis, from three independent embryos (n = 3). Electroporation with EGFP-C1 did not show any bias for either HCs or SC.