Table 3.

Kinetic constants for Sb influx at 25°C in WT and Sb^III-resistant L. braziliensis and L. guyanensis promastigotes.

Leishmania lines	INFLUX
	aKm (nM)	aVmax (nmol. s−1.cell−1)	bkinflux (L.s−1.cell−1)	kinflux WT/kinfluxR
L. braziliensis
Wild-type	1.7 ± 1.0 × 106	2.6 ± 0.2 × 10−11	1.6 × 10−17	1.8
Resistant	1.1 ± 0.6 × 106	1.1 ± 0.1 × 10−11	0.9 × 10−17
L. guyanensis
Wild-type	1.3 ± 0.3 × 106	2.0 ± 0.1 × 10−11	1.6 × 10−17	166
Resistant	−	−	0.1 × 10−18

^aThe values were obtained by nonlinear regression analysis according to the Michaelis-Menten model.

^bThe values were calculated through k_influx = V_max/K_m (Michaelis-Menten model) or through k_influx = Vi/Ce when no saturation was observed.