Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Sensitivity (IC50 ± SEM) of L. braziliensis and L. guyanensis strains to different ABC transporter inhibitors (verapamil, probenicid, prochlorperazine, BSO).
| Transporter | IC50 ±SEM | |||
|---|---|---|---|---|
| inhibitors | L. braziliensis | L. guyanensis | ||
| Wild-type | Resistant | Wild-type | Resistant | |
| Verapamil (μM) | 63.8 ± 1.8 | 27.0 ± 0.1 | 45.6 ± 3.4 | 82.7 ± 0.1 |
| Prochlorperazine (μM) | 7.5 ± 2.3 | 11.6 ± 0.1 | 3.5 ± 0.6 | 68.4 ± 0.1 |
| Probenecid (mM) | 204.5 ± 1.2 | 101.0 ± 0.2 | 503.5 ± 3.3 | 385.3 ± 31.5 |
| BSO (mM) | >100 | >100 | >100 | 53.4 ± 0.8 |
