Table 3. Cox regression model for predictor of atrial fibrillation development.

Variables	Model 1			Model 2			Model 3
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Gender
Female	1.00			1.00			1.00
Male	1.25	1.18-1.33	< 0.001	1.2	1.14-1.27	< 0.001	1.25	1.18-1.33	< 0.001
Age, y
18-40	1.00			1.00			1.00
41-65	6.45	5.05-8.24	< 0.001	7.62	5.99-9.69	< 0.001	6.47	5.07-8.27	< 0.001
≥ 65	26.95	21.11-34.42	< 0.001	33.1	26.01-42.11	< 0.001	27.09	21.21-34.59	< 0.001
Comorbidity
DM	0.95	0.89-1.02	0.15	0.96	0.90-1.02	0.22	0.95	0.89-1.02	0.15
Hypertension	1.25	1.16-1.34	< 0.001	1.23	1.15-1.32	< 0.001	1.25	1.17-1.35	< 0.001
Dyslipidemia	0.66	0.62-0.70	< 0.001	0.62	0.59-0.66	< 0.001	0.66	0.62-0.70	< 0.001
COPD	1.15	1.07-1.25	< 0.001	1.16	1.08-1.24	< 0.001	1.15	1.07-1.25	< 0.001
Congestive heart failure	2.20	2.05-2.36	< 0.001	2.14	2.00-2.28	< 0.001	2.20	2.05-2.36	< 0.001
Coronary artery disease	1.72	1.61-1.84	< 0.001	1.66	1.57-1.77	< 0.001	1.73	1.62-1.85	< 0.001
Chronic kidney disease	1.02	0.92-1.13	0.77	0.93	0.84-1.03	0.16	1.02	0.92-1.13	0.77
Stroke	0.94	0.86-1.02	0.15	0.82	0.75-0.89	< 0.001	0.94	0.86-1.02	0.14
Peripheral artery disease	0.93	0.76-1.13	0.45	0.92	0.76-1.11	0.38	0.93	0.76-1.13	0.46
Sleep apnea	0.81	0.42-1.56	0.53	0.47	0.21-1.04	0.06	0.81	0.42-1.56	0.53
Valvular heart diseases	0.99	0.83-1.19	0.93	1.08	0.92-1.27	0.35	0.99	0.83-1.19	0.95
Depression	0.89	0.69-1.08	0.12	0.87	0.65-1.12	0.14	0.89	0.69-1.08	0.12
Bipolar disorder	0.95	0.78-1.11	0.22	0.93	0.74-1.15	0.25	0.95	0.78-1.11	0.23
Insomnia
No	1.00			1.00
Yes	1.08	1.01-1.14	0.02	1.33	1.25-1.41	< 0.001
Insomnia
No							1.00
< 5 visits							1.16	1.05-1.28	0.004
5-9 visits							1.14	1.03-1.26	0.009
≥ 10 visits							1.00	0.92-1.08	0.93

Model 1, Non-insomnia cohort matched on sex, age, index date; Model 2, Non-insomnia cohort matched on sex, age, co-morbidity by using propensity score; Model 3, Insomnia frequency analysis between insomnia and Afib. Abbreviations are in Table 1.