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. 2017 Mar 24;9:71. doi: 10.3389/fnagi.2017.00071

Figure 5.

Figure 5

Reduction in intraneuronal human APP/Aβ expression by passive immunization with anti-human APP/Aβ antibody, 6E10, in the hippocampal CA3 region of 3-week-old 3xTg-AD mice. (A) Representative photomicrographs illustrating reduction in 6E10 (human APP/Aβ) intraneuronal immunoreactivity in the hippocampal CA3 region of young 3xTg-AD mice after passive immunization with 6E10. (B) Densitometric quantification of the immunohistochemistry data with 6E10 expression. (C) Representative photomicrographs showing decrease in APP-CT20 (human APP/CTFs) intraneuronal expression in the hippocampal CA3 region of young 3xTg-AD mice after passive immunization with 6E10. (D) Densitometric quantification of the immunohistochemistry data with APP-CT20 expression. The data are shown as mean ± SEM from Saline-3xTg-AD (n = 9) and 6E10–3xTg-AD (n = 9), and compared using Student’s t-test. Insets show the designated areas at higher magnification. Scale bar = 100 μm. *p < 0.05, **p < 0.01.