Table 5.
Mammalian PATs and their (regulated) target proteins.
| PAT | Targets | References |
|---|---|---|
| DHHC2 | PSD-95, CKAP4, SNAP23/25, eNOS, Fyn, NDE1, NDEL1, CD9/151, ABCA1, AKAP79/150 | Fukata et al., 2004; Huang et al., 2004; Fernández-Hernando et al., 2006; Sharma et al., 2008; Zhang et al., 2008; Shmueli et al., 2010; Singaraja et al., 2009; Greaves et al., 2010; Chavda et al., 2014 |
| DHHC3 (GODZ) | PSD-95, SNAP23/25/25b, Gα, CSP, Integrin α6β4, GABAAγ2, eNOS, GluR1/2, GAD65, STREX, Fyn, BACE1, NDE1, NDEL1, NCAM140, CaMKIγ, NR2A/B, DR4, PI4KII | Fukata et al., 2004; Keller et al., 2004; Hayashi et al., 2005; Fang et al., 2006; Fernández-Hernando et al., 2006; Takemoto-Kimura et al., 2007; Greaves et al., 2008; Huang et al., 2009; Mill et al., 2009; Tsutsumi et al., 2009; Vetrivel et al., 2009; Greaves et al., 2010; Tian et al., 2010; Shmueli et al., 2010; Yeste-Velasco et al., 2015 |
| DHHC4 | BACE1 | Vetrivel et al., 2009 |
| DHHC5 | Grip1b, δ-catenin, Flotillin-2, somatostatin receptor 5, Ankyrin-G, STREX | Tian et al., 2010; Kokkola et al., 2011; Li et al., 2012; Thomas et al., 2012; Brigidi et al., 2014, 2015 |
| DHHC6 | Chaperone calnexin | Lakkaraju et al., 2012 |
| DHHC7 | PSD-95, Gα, CSP, Fyn, eNOS, SNAP25/23/25b, GABAAγ2, STREX, BACE1, NDE1, NDEL1, NCAM140, sortillin, PDE10A2, CD9, ER, PR, AR, PI4KII | Fukata et al., 2004; Fang et al., 2006; Fernández-Hernando et al., 2006; Fukata et al., 2006; Greaves et al., 2008; Mccormick et al., 2008; Ponimaskin et al., 2008; Greaves et al., 2009; Tsutsumi et al., 2009; Vetrivel et al., 2009; Shmueli et al., 2010; Charych et al., 2010; Greaves et al., 2010; Tian et al., 2010; Ohno et al., 2012 |
| DHHC8 | eNOS, SNAP25, paralemmin-1, GAD65, PSD95, PSD93 | Fernández-Hernando et al., 2006; Mukai et al., 2008; Huang et al., 2009 |
| DHHC9 | H- and N-Ras, STREX | Swarthout et al., 2005; Tian et al., 2010 |
| DHHC12 | ABCA1 | Singaraja et al., 2009; Chavda et al., 2014 |
| DHHC13 (HIP14L) | MT1-MMP, HTT, GAD65 | Huang et al., 2009; Saleem et al., 2010; Song et al., 2014 |
| DHHC15 | PSD95, GAP43, SNAP25b, CSP, GABAAγ2, Fyn, BACE1, CD151, CI-MPR, sortillin | Fukata et al., 2004; Fang et al., 2006; Greaves et al., 2008; Mccormick et al., 2008; Sharma et al., 2008; Mill et al., 2009; Vetrivel et al., 2009; Greaves et al., 2010 |
| DHHC17 (HIP14) | PSD95, CLIP3, CSP, GAD65, GAP43, GLUR1/2, GPM6A, HTT, JNK3, Lck, SNAP25/23/25b, STREX, SYT1, SPRED1/3, Ras | Fukata et al., 2004; Ohyama et al., 2007; Greaves et al., 2008; Huang et al., 2009; Mill et al., 2009; Greaves et al., 2010; Tian et al., 2010; Ohno et al., 2012; Butland et al., 2014 |
| DHHC18 | H- and N-Ras, Lck | Fukata et al., 2004 |
| DHHC19 | R-Ras, PDE10A2 | Baumgart et al., 2010; Charych et al., 2010 |
| DHHC20 | Fyn, BACE1, ABCA1 | Mill et al., 2009; Singaraja et al., 2009; Vetrivel et al., 2009 |
| DHHC21 | PECAM1, SOD1, Lck, eNOS, Fyn, ABCA1, ER, PR, AR | Fernández-Hernando et al., 2006; Takemoto-Kimura et al., 2007; Mill et al., 2009; Vetrivel et al., 2009; Antinone et al., 2013; Akimzhanov and Boehning, 2015; Yeste-Velasco et al., 2015 |