Figure 3.

OPLS-DA and S-plot analysis comparing the OPLSDA scores between sham and acoustic trauma animals in different brain regions. Left panel, OPLSDA scores plots, red dots: Sham, purple dots: Acoustic trauma; Right panel, S-plots. (A,B) AC (Predictive component: R²X = 0.194, R²Y = 0.76, Q2 = 0.45; Orthogonal component 1: R²X = 0.446; All components: R²X (cum) = 0.64); (C,D) CB (Predictive component: R²X = 0.152, R²Y = 0.973, Q2 = 0.68; Orthogonal component 1: R²X = 0.364; All components: R²X (cum) = 0.927); (E,F) IC (Predictive component: R²X = 0.293, R²Y = 0.978, Q2 = 0.702; Orthogonal component 1: R²X = 0.417; All components: R²X (cum) = 0.905); (G,H) SC (Predictive component: R²X = 0.238, R²Y = 0.791, Q2 = 0.691; Orthogonal component: R²X = 0.562; All components: R²X (cum) = 0.8); (I,J) VNC(Predictive component: R²X = 0.403, R²Y = 0.779, Q2 = 0.445; Orthogonal component: R²X = 0.389; All components: R²X (cum) = 0.792). AC, auditory cortex; CB, cerebellum; IC, inferior colliculus; CN, cochlear nucleus; VCN, vestibular nucleus complex.