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. 2017 Mar 24;11:75. doi: 10.3389/fncel.2017.00075

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Copyright © 2017 Cheng, Song and Augustine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of TRPC channels in presynaptic action of BDNF on spontaneous GABA release in TKO neurons. (A) Time course of changes in normalized mIPSC frequency during BDNF application for TWT neurons without (black, n = 21) and with (olive green, n = 12) SKF96365 (3 μM). (B) Changes in mIPSC frequency during 6th minute of BDNF application in TWT neurons, with and without SKF96365 treatment. (C) Time course of changes in normalized mIPSC frequency in TKO neurons during BDNF application without (red, n = 18) and with (turquoise, n = 12) SKF96365 treatment. (D) Changes in mIPSC frequency in TKO neurons during 6th minute of BDNF application, with and without SKF96365. (E) Time course of changes in normalized mIPSC frequency in TKO neurons during BDNF application without (red, n = 18) and with (sky blue, n = 8) Pyr3 treatment (3 μM). (F) Changes in mIPSC frequency in TKO neurons during 6th minute of BDNF application, with and without Pyr3.