Table 1.
Effect of Alternaria and Fusarium toxins of the activity of type IIA topoisomerases human topo II α and bacterial gyrase
| Initial inhibitory conc. (μM) | ||
|---|---|---|
| h topo II α | Gyrase | |
| Alternaria spp. | ||
| Perylene chinones | ||
| ATX I | ++ | +++ |
| ATX II | ++++ | ++++ |
| ALP | ++ | +++ |
| STTX III | +++++ | +++ |
| Dibenzo-α-pyrones | ||
| AOH | ++++a | +++++ |
| AME | ++++a | +++++ |
| Others | ||
| ALN | +++ | – |
| ALS | ++++ | – |
| PYR | +++ | – |
| MAC | – | – |
| TEN | – | – |
| Fusarium spp. | ||
| FB1 | – | – |
| FC | – | – |
| MON | – | – |
| DON | – | – |
Effects of mycotoxins on human recombinant topo II α (h topo II α) and bacterial gyrase based on at least three independent experiments (initial inhibition at: 10 µM (+++++), 25 µM (++++), 50 µM (+++), 75 µM (++) and 150 µM (+); no inhibition up to 150 µM (–))
aFehr et al. (2009)