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. 2017 Mar 23;85(4):e00007-17. doi: 10.1128/IAI.00007-17

FIG 1.

FIG 1

Analysis of anhedonic behavior by sucrose consumption following T. gondii infection. (A) Sucrose consumption by wild-type BALB/c mice after injection with PBS or infection with T. gondii. Data from two independent experiments are summarized and presented as means ± standard deviations [PBS, n = 4 plus 6; T. gondii, n = 2 plus 6 (two mice died due to infection during trial 1); F(30, 496) = 4.15; P < 0.0001]. * indicates a significant difference between the PBS-injected and T. gondii-infected groups by two-way ANOVA plus Bonferroni post hoc analysis. (B) Sucrose consumption of wild-type BALB/c mice after injection with PBS or infection with T. gondii under treatment with Mino (10 mg/kg i.p.) or injection with PBS from days 4 to 7 postinfection. Data are representative of data from two independent experiments with similar results and are presented as means ± standard deviations [n = 6; F(42, 300) = 3.27; P < 0.0001]. * indicates a significant difference between the PBS-PBS and T. gondii-PBS groups, and # indicates a significant difference between the T. gondii-PBS and T. gondii-Mino groups by two-way ANOVA plus Bonferroni post hoc analysis. (C) Sucrose consumption of wild-type BALB/c mice (IFN-γ+/+) and IFN-γ−/− mice after injection with PBS or infection with T. gondii. Data are representative of data from four independent experiments with similar results and are presented as means ± standard deviations [n = 5; F(30, 176) = 3.77; P < 0.0001]. * indicates a significant difference between the PBS–IFN-γ+/+ and T. gondii–IFN-γ+/+ groups, and # indicates a significant difference between the T. gondii–IFN-γ+/+ and T. gondii–IFN-γ−/− groups by two-way ANOVA plus Bonferroni post hoc analysis. (D) Sucrose consumption of wild-type BALB/c mice after injection with PBS or infection with T. gondii under treatment with 1-MT (50 mg/kg subcutaneously) or injection with the vehicle from days 4 to 7 postinfection. Data are representative of data from two independent experiments with similar results and are presented as means ± standard deviations [n = 6; F(42, 300) = 4.24; P < 0.0001]. * indicates a significant difference between the PBS-vehicle and T. gondii-vehicle groups, and # indicates a significant difference between the T. gondii-vehicle and T. gondii–1-MT groups by two-way ANOVA plus Bonferroni post hoc analysis.