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Schematic model demonstrating PepO-induced signaling transduction in macrophages. PepO induces upregulation of miR-155 in a TLR2-, NF-κB-, and Akt-dependent manner. miR-155 inhibits expression of SHIP1, and SHIP1 downregulation leads to augmented activity of CR3, which may promote phagocytosis of bacteria by macrophages.
