Table 2.
Baseline characteristics of eligible contacts and contacts of contacts
|
Randomly assigned |
Not randomly assigned* |
Totality of evidence |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Assigned to immediate vaccination (51 clusters, n=3232) |
Assigned to delayed vaccination (47 clusters, n=3096) |
Assigned to immediate vaccination (19 clusters, n=2006) |
All clusters (117 clusters, n=8334) |
||||||
| Consent | No consent | Consent visit day 0† | Consent visit day 21† | No consent | Consent | No consent | Immediately vaccinated | Delayed or never vaccinated | |
| Individuals' characteristics | |||||||||
| Number of individuals | 2151 | 1081 | 1435 | 1104 | 557 | 1678 | 328 | 3796 | 4538 |
| Age (years) | 40 (29–55) | 30 (25–45) | 39 (27–53) | 37 (27–50) | 32 (23–45) | 30 (22–44) | 25 (18–35) | 35 (25–50) | 35 (25–50) |
| Women | 640/2151 (30%) | 608/1081 (56%) | 428/1434 (30%) | 404/1104 (37%) | 319/557 (57.3%) | 593/1678 (35%) | 179/328 (54.6%) | 1223/3796 (32%) | 1948/4537 (43%) |
| Contacts with index cases | |||||||||
| No detailed contact information (no consent) | 0/2151 | 1081/1081 (100%) | 0/1435 | 0/1104 | 557/557 (100%) | 0/1678 | 328/328 (100%) | 0/3796 | 1966/4538 (43%) |
| Contact of contact‡ | 1727/2151 (80%) | .. | 1160/1435 (81%) | 971/1104 (88%) | .. | 1418/1678 (85%) | .. | 3116/3796 (82%) | 2160/2572 (84%) |
| Contact‡ | 424/2151 (20%) | .. | 275/1435 (19%) | 133/1104 (12%) | .. | 260/1678 (15%) | .. | 680/3796 (18%) | 412/2572 (16%) |
| High-risk contact‡ | 330/2151 (15%) | .. | 171/1435 (12%) | 58/1104 (5%) | .. | 246/1678 (15%) | .. | 574/3796 (15%) | 231/2572 (9%) |
Data are median (IQR) or n/N (%). ..=data not available.
*
Six non-randomised rings included children aged 6 years and older (n=273).
†
Informed consent was obtained either during the first visit (day 0) or the second visit (day 21) of the trial team.
‡
Proportion calculated among individuals with available contact information. Two individuals were pregnant and one was severely ill.