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Hypoxia induced expression of CSC marker and chemoresistance in HCC cells. (A) and (B) PLC/PRF/5 and Huh7 cells were cultured in either normoxic or hypoxic condition for 5 days. The ALDH activity and expression of CD133 were examined by flow cytometry. (C) The specificity of ALDH detection was confirmed by DEAB inhibition. (D–F) After 72 h exposure, the cytotoxicity of 5-FU and sorafenib was determined in HCC cell lines cultured at normoxic and hypoxic conditions. **P < 0.01.
