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. 2017 Feb;13(2):641–657. doi: 10.1016/j.nano.2016.08.001

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

DS-PLGA inhibited hypoxia-induced CSC marker expression, eradicated sphere forming ability and clonogenicity in HCC cell lines. (A) Percentage of ALDH and CD133 positive cells. The HCC cells were cultured at hypoxic condition for 5 days and subjected to different treatments for 4 h (DS represents DS-PLGA). (B) After exposure of sphere cells to different drugs for 24 h, the ALDH and CD133 positive population was examined by flow cytometry (DS represents DS-PLGA). (C) and (D) DS-PLGA/Cu blocked the sphere-forming ability in HCC cell. (E) and (F) DS-PLGA/Cu induced apoptosis in sphere cells. (G) and (H) DS-PLGA/Cu eradicated clonogenicity in HCC cell lines. n = 3; **P < 0.01.

DS-PLGA inhibited hypoxia-induced CSC marker expression, eradicated sphere forming ability and clonogenicity in HCC cell lines. (A) Percentage of ALDH and CD133 positive cells. The HCC cells were cultured at hypoxic condition for 5 days and subjected to different treatments for 4 h (DS represents DS-PLGA). (B) After exposure of sphere cells to different drugs for 24 h, the ALDH and CD133 positive population was examined by flow cytometry (DS represents DS-PLGA). (C) and (D) DS-PLGA/Cu blocked the sphere-forming ability in HCC cell. (E) and (F) DS-PLGA/Cu induced apoptosis in sphere cells. (G) and (H) DS-PLGA/Cu eradicated clonogenicity in HCC cell lines. n = 3; **P < 0.01.