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Functional pleiotropy of CPI-17 due to subcellular distribution. CPI-17 is accumulated in the nucleus of proliferating smooth muscle and cancer cells. The nuclear CPI-17 regulates phosphorylation of histone(s) and MEF2C, but not canonical MLCP substrates, such as myosin light chain and ezrin/moecin/radixin. A nuclear localization signal exists at the N-terminal tail of CPI-17. Phosphorylation of CPI-17 at Ser12 interferes the nuclear accumulation.
