Table 2. Effect of LOS or PKCγ siRNA on MDA, SOD, GSH levels and NAD(P)H oxidase activity in PVN of salt-induced hypertensive and control groups (n = 7, for each group).
PVN | MDA (mmol/mgp) | SOD (U/mgp) | GSH (umol/mgp) | NAD(P)H oxidase (RLU/mg/sec) |
---|---|---|---|---|
HS + PVN LOS | 4.87 ± 0.19†,∗ | 6.26 ± 0.30†,∗ | 2.85 ± 0.24†,∗ | 1.91 ± 1.20†,∗ |
HS + PVN aCSF | 7.01 ± 0.24∗ | 2.67 ± 0.10∗ | 0.98 ± 0.13∗ | 3.69 ± 1.41∗ |
NS + PVN LOS | 1.68 ± 0.22 | 9.61 ± 0.40 | 4.76 ± 0.15 | 0.93 ± 0.34 |
NE + PVN aCSF | 1.25 ± 0.21 | 10.00 ± 1.40 | 5.18 ± 0.37 | 0.87 ± 0.29 |
HS + PVN PKC siRNA | 3.82 ± 0.14†,∗ | 4.57 ± 0.17†,∗ | 1.99 ± 0.18†,∗ | 2.80 ± 1.16†,∗ |
HS + PVN scrambled siRNA | 6.28 ± 0.24∗ | 3.67 ± 0.15∗ | 0.98 ± 0.13∗ | 4.27 ± 1.78∗ |
NS + PVN PKC siRNA | 2.55 ± 0.13 | 7.11 ± 0.37 | 3.24 ± 0.12 | 1.33 ± 0.32 |
NE + PVN scrambled siRNA | 2.68 ± 0.14 | 7.85 ± 0.44 | 2.97 ± 0.11 | 1.18 ± 0.26 |
Values are expressed as means SE. *P < 0.05 versus NS groups; †P < 0.05 HS + PVN LOS or HS + PVN PKC siRNA versus HS control groups.