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. 2017 Mar 24;7:42928. doi: 10.1038/srep42928

Figure 7. TIGAR low-expression inhibits IR-induced Trx1 nuclear translocation in TrxR1-overexpressing xenograft models.

Figure 7

TIGAR, TrxR1 and Trx1 expression in xenografts was shown by immunohistochemistry staining (400x) performed post 20-Gy fractionated radiotherapy. (a) Sham IR. (b) 20-Gy fractionated IR (scale bar = 50 μm). (c,d) Western blot analysis of protein expression levels in freshly harvested xenografts. *p < 0.05, pcDNA3.1 vs. pcDNA3.1-TrxR1, #p < 0.05, pcDNA3.1-TrxR1 vs. pcDNA3.1-TrxR1+ TIGAR shRNA, $p < 0.05, pcDNA3.1 vs. pcDNA3.1+ TIGAR shRNA.