Table 2. L18 plan for statistical parameter design in performance optimization of the assessment method.

Run	Parameter					Results
	Drug Conductivity [μS/cm]	Signal Frequency [kHz]	Electrodes Area [cm2]	Electrodes Gap [cm]	Signal Amplitude [V]	Sensitivity [ml−1]	Repeatabi-lity [%]	Nonlinea-rity [%]	Resolution [ml]
1	526	0.1	1.82	1.4	0.020	5.6	2.99	2.34	0.130
2	526	0.1	3.64	3.0	0.100	4.7	0.05	0.78	0.036
3	526	0.1	7.28	4.6	1.000	3.0	0.16	3.74	0.115
4	526	1.0	1.82	1.4	0.100	4.7	1.02	4.26	0.197
5	526	1.0	3.64	3.0	1.000	4.3	0.34	3.16	0.140
6	526	1.0	7.28	4.6	0.020	3.1	0.03	3.69	0.118
7	526	10.0	1.82	3.0	0.020	4.3	0.89	2.54	0.107
8	526	10.0	3.64	4.6	0.100	2.7	0.32	3.80	0.098
9	526	10.0	7.28	1.4	1.000	2.9	0.05	2.82	0.083
10	666	0.1	1.82	4.6	1.000	4.0	0.80	1.37	0.055
11	666	0.1	3.64	1.4	0.020	4.4	0.82	1.50	0.067
12	666	0.1	7.28	3.0	0.100	2.4	0.09	7.62	0.190
13	666	1.0	1.82	3.0	1.000	6.0	3.25	0.82	0.049
14	666	1.0	3.64	4.6	0.020	3.8	0.54	0.47	0.018
15	666	1.0	7.28	1.4	0.100	6.4	0.95	2.26	0.113
16	666	10.0	1.82	4.6	0.100	3.6	0.61	1.00	0.036
17	666	10.0	3.64	1.4	1.000	6.7	2.15	0.94	0.062
18	666	10.0	7.28	3.0	0.020	2.5	0.10	2.79	0.073
				Overall mean		4.2	0.84	2.55	0.09