Table 3. Non-covalent interactions of complexes 1 and 2 with the Human–DNA–Topo–I.

Name	Distance (Å)	Category	Type
D:Complex 1:H - B:DT10:O2	2.89	Hydrogen Bond	Conventional
B:DT10 - D: Complex 1	4.26		Pi-Pi T-shaped
C:DG12 - D: Complex 1	4.96		Pi-Pi T-shaped
D:DA113 - D: Complex 1	5.20		Pi-Pi T-shaped
D:Complex 1:C - A:LEU721	5.43		Alkyl
B:DT10 - D: Complex 1:C	5.48	Hydrophobic	Pi-Alkyl
C:DG12 - D: Complex 1:C	2.70		Pi-Alkyl
C:DG12 - D: Complex 1:C	5.20		Pi-Alkyl
C:DG12 - D: Complex 1:C	3.16		Pi-Alkyl
D:DA113 - D:Complex 2	5.58		Pi-Pi Stacked
C:DG12 - D: Complex 2	4.26		Pi-Pi T-shaped
D: Complex 2 - C:DG12	3.93		Pi-Pi T-shaped
C:DG12 - D: Complex 2:C	2.47		Pi-Alkyl
C:DG12 - D: Complex 2:C	3.55	Hydrophobic	Pi-Alkyl
C:DG12 - D: Complex 2:C	4.72		Pi-Alkyl
D:DC111 - D: Complex 2:C	5.07		Pi-Alkyl
D:DC112 - D: Complex 2:C	3.68		Pi-Alkyl
D:DA113 - D: Complex 2:C	4.22126		Pi-Alkyl