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. 2017 Mar 23;18:250. doi: 10.1186/s12864-017-3621-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Motif search in promoter region of correlated genes show enrichment for CG-rich motifs. a Motifs enriched in significantly methylation/expression correlated 1 kb upstream of the TSS compared to non-correlated genes. b Average number of CpG-islands present in 1 kb upstream from the promoter in both groups compared to number of promoters in each groups. c Boxplots to the right show the GC frequency of the significantly and non-significantly correlated genes. μ represents the mean for each group. p-value was calculated using the Students’ t-test