Table 2.
Index year and AED
| Overall population | Matched population | |||||
|---|---|---|---|---|---|---|
| EIAED (n = 2752) |
nEAAED (n = 2137) |
p valuea | EIAED (n = 951) |
nEAAED (n = 951) |
p valuea | |
| Year of index, n (%) | <0.0001 | 0.0669 | ||||
| 2001 | 298 (10.8) | 70 (3.3) | 45 (4.7) | 55 (5.8) | ||
| 2002 | 326 (11.8) | 88 (4.1) | 53 (5.6) | 63 (6.6) | ||
| 2003 | 312 (11.3) | 121 (5.7) | 86 (9.0) | 72 (7.6) | ||
| 2004 | 402 (14.6) | 147 (6.9) | 109 (11.5) | 85 (8.9) | ||
| 2005 | 314 (11.4) | 190 (8.9) | 106 (11.1) | 96 (10.1) | ||
| 2006 | 275 (10.0) | 222 (10.4) | 121 (12.7) | 109 (11.5) | ||
| 2007 | 256 (9.3) | 255 (11.9) | 121 (12.7) | 119 (12.5) | ||
| 2008 | 225 (8.2) | 293 (13.7) | 106 (11.1) | 123 (12.9) | ||
| 2009 | 206 (7.5) | 371 (17.4) | 130 (13.7) | 119 (12.5) | ||
| 2010 | 138 (5.0) | 380 (17.8) | 74 (7.8) | 110 (11.6) | ||
| Index AED, n (%) | <0.0001 | <0.0001 | ||||
| EIAED cohort | ||||||
| Carbamazepine | 1742 (63.3) | — | 690 (72.6) | — | ||
| Phenytoin | 971 (35.3) | — | 245 (25.8) | — | ||
| Phenobarbital | 26 (0.9) | — | 9 (0.9) | — | ||
| Primidone | 13 (0.5) | — | 7 (0.7) | — | ||
| nEAAED cohort | ||||||
| Lamotrigine | — | 1239 (58.0) | — | 632 (66.5) | ||
| Gabapentin | — | 448 (21.0) | — | 149 (15.7) | ||
| Levetiracetam | — | 261 (12.2) | — | 126 (13.2) | ||
| Pregabalin | — | 185 (8.7) | — | 41 (4.3) | ||
| Zonisamide | — | 2 (0.1) | — | 2 (0.2) | ||
| Vigabatrin | — | 2 (0.1) | — | 1 (0.1) | ||
Abbreviations: AED antiepileptic drug, EIAED enzyme-inducing antiepileptic drug, nEAAED non-enzyme–active antiepileptic drug
aChi-square test