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. 2017 Mar 23;23:18. doi: 10.1186/s40409-017-0104-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Involvement of cytokines on MT-II-induced articular hyperalgesia. MT-II (10 μg/joint) or PBS (vehicle) was injected in tibio-tarsal articulation (25 μL). Pain threshold was determined using a modified electronic pressure-meter test 8 h after MT-II injection, and represented as force (in g). a anti-TNFα antibody (0.5 μg/joint) or (b) anti-IL-1β antibody (1.5 μg/joint) or (c) anti-IL-6 antibody (4.0 μg/joint) or (d) anti-CINC-1 antibody (5.0 μg/joint) was injected 30 min before MT-II. Each point represents the mean ± SEM of six animals. *** p < 0.001 indicate statistically significant differences when compared with control group (vehicle + vehicle). ### p < 0.001 indicate statistically significant differences when compared with MT-II group (MT-II + vehicle)