Fig. 7.

Involvement of endothelin on MT-II-induced articular hyperalgesia. MT-II (10 μg/joint) or PBS (vehicle) was injected in tibio-tarsal articulation (25 μL). Pain threshold was determined using a modified electronic pressure-meter test 8 h after MT-II injection, and represented as force (in g). a BQ-123 or (b) BQ-788 (10 and 20 nmol/joint, selective antagonists of ET-A and ET-B endothelin receptors, respectively) were injected 30 min before MT-II. Each point represents the mean ± SEM of six animals. **p < 0.01 and ***p < 0.001 indicate statistically significant differences when compared with control group (vehicle + vehicle). #p <0.05 and ### p < 0.001 indicate statistically significant differences when compared with MT-II group (MT-II + vehicle)