Table 2.
Association of admission glucocorticoid levels with short- and long-term all-cause mortality in community-acquired pneumonia
| Entire cohort (N = 285) | All-cause mortality time point | |||||
|---|---|---|---|---|---|---|
| 30 days | 3 years | 6 years | ||||
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Cortisol | ||||||
| Cox regression analyses | ||||||
| Univariate model | 2.47 (95% CI 0.50–12.18) | 0.268 | 0.54 (95% CI 0.32–0.9) | 0.018 | 0.63 (95% CI 0.41–0.99) | 0.045 |
| Multivariate modela | 1.93 (95% CI 0.51–9.02) | 0.405 | 0.53 (95% CI 0.32–0.89) | 0.017 | 0.57 (95% CI 0.36–0.90) | 0.015 |
| 11-Deoxycortisol | ||||||
| Cox regression analyses | ||||||
| Univariate model | 1.37 (95% CI 0.75–2.53) | 0.309 | 0.95 (95% CI 0.76–1.18) | 0.631 | 1.04 (95% CI 0.86–1.24) | 0.710 |
| Multivariate modela | 1.26 (95% CI 0.65–2.44) | 0.486 | 0.84 (95% CI 0.67–1.05) | 0.126 | 0.91 (95% CI 0.75–1.1) | 0.336 |
| Cortisone | ||||||
| Cox regression analyses | ||||||
| Univariate model | 1.37 (95% CI 0.31–6.02) | 0.677 | 0.56 (95% CI 0.33–0.94) | 0.028 | 0.6 (95% CI 0.38–0.95) | 0.030 |
| Multivariate modela | 2.55 (95% CI 0.38–17.30) | 0.337 | 0.71 (95% CI 0.4–1.25) | 0.237 | 0.76 (95% CI 0.46–1.24) | 0.272 |
| Corticosterone | ||||||
| Cox regression analyses | ||||||
| Univariate model | 1.33 (95% CI 0.63–2.81) | 0.457 | 0.77 (95% CI 0.57–1.03) | 0.082 | 0.85 (95% CI 0.66–1.09) | 0.199 |
| Multivariate modela | 1.21 (95% CI 0.55–2.65) | 0.637 | 0.76 (95% CI 0.57–1.02) | 0.067 | 0.81 (95% CI 0.63–1.03) | 0.084 |
Data for univariate and multivariate Cox regression models are presented as HR (95% CI), p value; p < 0.05 is considered statistically significant. Bold values indicate statistical significance. All hormone levels were log-transformed, and thus the HR corresponds to a tenfold increase in these levels
aMultivariate model is adjusted for age, sex, and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)