Table 3.
Association of admission glucocorticoid levels with short-term adverse outcome in community-acquired pneumonia
| Entire cohort (N = 285) | Adverse outcome at 30 days (death and/or ICU admission) | |
|---|---|---|
| OR (95% CI) | p Value | |
| Cortisol | ||
| Logistic regression analyses | ||
| Univariate model | 4.16 (95% CI 1.22–14.12) | 0.022 |
| Multivariate modela | 3.85 (95% CI 1.10–13.49) | 0.035 |
| 11-Deoxycortisol | ||
| Logistic regression analyses | ||
| Univariate model | 1.33 (95% CI 0.84–2.11) | 0.216 |
| Multivariate modela | 1.30 (95% CI 0.80–2.14) | 0.293 |
| Cortisone | ||
| Logistic regression analyses | ||
| Univariate model | 1.89 (95% CI 0.59–1.03) | 0.280 |
| Multivariate modela | 3.25 (95% CI 0.84–12.68) | 0.089 |
| Corticosterone | ||
| Logistic regression analyses | ||
| Univariate model | 1.41 (95% CI 0.81–2.47) | 0.225 |
| Multivariate modela | 1.44 (95% CI 0.79–2.62) | 0.234 |
ICU, Intensive care unit
Data for univariate and multivariate logistic regression models are presented as OR (95% CI), p value; p < 0.05 is considered statistically significant. Bold values indicate statistical significance. All hormone levels were log-transformed, and thus the OR corresponds to a tenfold increase in levels
aMultivariate model is adjusted for age, sex, and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)