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. 2017 Mar 23;18:186. doi: 10.1186/s12859-017-1576-1

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Estimated networks structure using the SPACE and ESPACE methods. The nodes with more than 7 connections (the 0.95 quantile in the degree distribution) were defined as hub nodes, which are represented as black nodes in the network structure. The details of hub genes are reported in Table 7. a SPACE (114 nodes, 234 edges) and b ESPACE (132 nodes, 272 edges)