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. 2017 Mar 23;16:62. doi: 10.1186/s12944-017-0452-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Two of the major tight junction proteins, ZO-1 and Claudin-8, were stained different grades of brown by immunohistochemistry (X 400). The brown staining of the proximal colonic epithelia lining villi in the propionic acid group (c, d) was greater compared to the control group (a, b)