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. 2017 Mar 23;18:35. doi: 10.1186/s12881-017-0400-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig 3 — Schematic structure of otoferlin and conservation analysis. a The functional domains of otoferlin and location of the mutations identified in the study. b Conservation of the L1665P of otoferlin. TMD: the transmembrane domain