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. 2017 Mar 23;36:46. doi: 10.1186/s13046-017-0515-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — SOX3-induced EMT is mediated by Snail1 transcription factor. a siRNA against Snail1 abolished the increased cell ability of migration and invasion produced by SOX3 overexpression. b Snail1 plasmid (Snail1) significantly rescued the decreased cell migration and invasion produced by SOX3 knockdown. c, d the alterations of EMT markers by SOX3 were also reversed by siSnail1 or Snail1 plasmid. The results are expressed as the mean ± SD of triplicate samples; * P < 0.05, **P < 0.01