Table 3.
Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the joint effects of total grilled–smoked meat intake (lifetime servings) and cytochrome P450 genotype, Long Island Breast Cancer Study Project (n = 2009)
| Gene (rs id) | Lifetime servings grilled–smoked meat* | OR† (95% CI) | ICR‡ (95% CI), indicating additive interaction |
|---|---|---|---|
| CYP1A1 (rs1048943) | |||
| AA | Low | Ref. | — |
| AA | High | 1.22 (0.96–1.57) | — |
| AG + GG | Low | 1.15 (0.64–2.05) | — |
| AG + GG | High | 0.55 (0.30–1.03) | −0.82 (−1.62 to −0.01) |
| CYP1B1 (rs10175338) § | |||
| GG | Low | Ref. | — |
| GG | High | 1.54 (1.12–2.11) | — |
| GT + TT | Low | 1.67 (1.20–2.33) | — |
| GT + TT | High | 1.24 (0.88–1.73) | −0.97 (−1.72 to −0.23) |
| CYP3A4 (rs2242480) | |||
| CC | Low | Ref. | — |
| CC | High | 1.00 (0.78–1.30) | — |
| CT + TT | Low | 1.07 (0.72–1.60) | — |
| CT + TT | High | 1.83 (1.20–2.80) | 0.75 (−0.06 to 1.57) |
| Number of “at-risk” alleles|| | |||
| 0–3 alleles | Low | Ref. | — |
| 0–3 alleles | High | 1.20 (0.93–1.55) | — |
| 4–6 alleles | Low | 1.61 (1.03–2.53) | — |
| 4–6 alleles | High | 1.49 (0.91–2.45) | −0.32 (−1.33 to 0.69) |
Ref. = reference.
Low = 0–4296 times consumed, High = 4297–51,652 times consumed.
Adjusted for age at diagnosis, energy intake, fruit and vegetable intake, and multivitamin supplement use.
Interaction contrast ratio (ICR) indicating interaction on the additive scale. In the absence of interaction, ICR = 0.
rs10175338 is in linkage disequilibrium with rs10175368; only the results for rs10175338 are presented.
The “at-risk” allele was defined as follows: CYP1A1 (rs1048943): A allele; CYP1B1 (rs10175338): T allele; CYP3A4 (rs2242480): T allele.