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. 2016 Dec 29;15(2):613–626. doi: 10.3892/mmr.2016.6083

Figure 4.

Figure 4.

DMN and YGD regulate mRNA and protein expression levels of α-SMA, CXCR4, ERK1/2, NF-κB p65 and β-catenin. Mice were injected with DMN or normal saline for 4 weeks. Following 4 weeks of DMN treatment, mice were treated with YGD or HGF for a further 4 weeks. (A) The protein expression levels of α-SMA, CXCR4, ERK1/2, NF-κB p65 and β-catenin were detected by western blotting and (B) the western blots were quantified. aP<0.05 vs. control; bP<0.05 vs. model week 4; cP<0.05 vs. YGD week 1; dP<0.05 vs. YGD week 2; and eP<0.05 vs. YGD week 3. (C) Reverse transcription-quantitative polymerase chain reaction was performed to analyze the mRNA expression levels. aP<0.05 vs. model week 4; bP<0.05 vs. YGD week 1; cP<0.05 vs. YGD week 2; and dP<0.05 vs. YGD week 3. YGD, Yi Guan Jian decoction; DMN, dimethylnitrosamine; α-SMA, α-smooth muscle actin; CXCR4, C-X-C chemokine receptor type 4; ERK1/2, extracellular signal-regulated kinase 1/2; NF-κB p65, nuclear factor κB p65 subunit; C, control; M, model; W, week.