Table I.
Effect of Met on the heart rate of SHR following downregulation of cardiac β1-AR expression.
| Group | No. of samples | Heart rate prior to Met intervention (bmp) | Heart rate following Met intervention (bmp) |
|---|---|---|---|
| Sham+Met | 4 | 461.7±3.7 | 435.7±3.3a |
| rAAV9-NC+Met | 6 | 459.9±6.0 | 434.1±2.6a |
| rAAV9-Adrb1+Met | 6 | 459.0±3.0 | 437.2±2.3a |
a
P<0.001 vs. each group prior to Met intervention. Met, metoprolol; SHR, spontaneously hypertensive rats; β1-AR, β1-adrenergic receptor; rAAV9, recombinant adeno-associated virus type 9 vector; NC, negative control; Adrb1, adrenergic receptor β1; bmp, beats per minute.