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. 2017 Feb 22;15(4):2143–2153. doi: 10.3892/mmr.2017.6239

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Kyoto Encyclopedia of Genes and Genomes pathways associated with T2DM and T2DM candidate genes regulated by the differentially expressed miRNAs. (A) Insulin signaling pathway (B) Pathways of adipocytokine signaling and type II diabetes mellitus. Red represents overexpressed genes targeted by downregulated miRNAs, and green represents repressed genes targeted by upregulated miRNAs. Orange and pea green represent genes targeted by both downregulated and upregulated miRNAs, although the former was primarily overexpressed and the latter was repressed. miR, microRNA; T2DM, type 2 diabetes mellitus; CACNA1E, calcium voltage-gated channel subunit α1 E; KIR, inward rectifying potassium channel; SUR1, sulfonylurea receptor 1; GLUT2, glucose transporter 2; TNFα, tumor necrosis factor α; TNFRSF1B, receptor superfamily, member 1B; IRS, insulin receptor substrate; INSR, INS receptor; SOCS3, suppressor of cytokine signaling 3; PPARGC1A, peroxisome proliferator-activated receptor γ, coactivator 1α; PPARA, peroxisome proliferator-activated receptor α; PRKAA1/2, protein kinase, AMP-activated, α1 and 2; AKT1, v-akt murine thymoma viral oncogene homolog 1; GTP-1, glutamate pyruvate transaminase-1; SLC2A1, solute carrier family 2, member 1; G6PC, glucose-6-phosphatase, catalytic subunit; LEP, leptin; LEPR, leptin receptor; ADIPO, adiponectinp; ADIPOR, adiponectin receptor; SHC1, Src homology 2 domain containing, transforming protein 1; MAP2K1, mitogen-activated protein kinase kinase 1; RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1; ACC, acetyl-CoA carboxylase; PDE3B, phosphodiesterase 3B; FOXO1, forkhead box O1; ERK, extracellular signal-regulated kinase.

Figure 7. — Kyoto Encyclopedia of Genes and Genomes pathways associated with T2DM and T2DM candidate genes regulated by the differentially expressed miRNAs. (A) Insulin signaling pathway (B) Pathways of adipocytokine signaling and type II diabetes mellitus. Red represents overexpressed genes targeted by downregulated miRNAs, and green represents repressed genes targeted by upregulated miRNAs. Orange and pea green represent genes targeted by both downregulated and upregulated miRNAs, although the former was primarily overexpressed and the latter was repressed. miR, microRNA; T2DM, type 2 diabetes mellitus; CACNA1E, calcium voltage-gated channel subunit α1 E; KIR, inward rectifying potassium channel; SUR1, sulfonylurea receptor 1; GLUT2, glucose transporter 2; TNFα, tumor necrosis factor α; TNFRSF1B, receptor superfamily, member 1B; IRS, insulin receptor substrate; INSR, INS receptor; SOCS3, suppressor of cytokine signaling 3; PPARGC1A, peroxisome proliferator-activated receptor γ, coactivator 1α; PPARA, peroxisome proliferator-activated receptor α; PRKAA1/2, protein kinase, AMP-activated, α1 and 2; AKT1, v-akt murine thymoma viral oncogene homolog 1; GTP-1, glutamate pyruvate transaminase-1; SLC2A1, solute carrier family 2, member 1; G6PC, glucose-6-phosphatase, catalytic subunit; LEP, leptin; LEPR, leptin receptor; ADIPO, adiponectinp; ADIPOR, adiponectin receptor; SHC1, Src homology 2 domain containing, transforming protein 1; MAP2K1, mitogen-activated protein kinase kinase 1; RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1; ACC, acetyl-CoA carboxylase; PDE3B, phosphodiesterase 3B; FOXO1, forkhead box O1; ERK, extracellular signal-regulated kinase.