REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Guinea pig Anti-Mouse K5	Fuchs Lab	N/A
Rabbit Anti-Mouse K14	Fuchs Lab	N/A
Rabbit Anti-Mouse K17	Fuchs Lab	N/A
Guinea pig Anti-Mouse K6	Fuchs Lab	N/A
Rabbit Anti- K10 Clone: Poly19054	Biolegend (Covance)	Cat# 905401
Rabbit Anti Cleaved Caspase-3 Clone: 269518	R&D	Cat# MAB 835
Armenian Hamster Anti-gd TCR Clone: GL3 AF647	Biolgend	Cat# 118133
Armenian Hamster Anti-gd TCR Clone: GL3	Biolgend	Cat# 118101
Rabbit Anti-pStat3 (Tyr705) Clone:D3A7	Cell Signaling	Cat# 9145
Rat Anti-CD104 Clone: 346-11A	Biolegend	Cat#123602
Syrian Hamster Anti-Mouse TCR Vg3 Clone: 536	Biolegend	Cat# 137505
Rat Anti-Mouse CD3e Clone: 17A2	Biolegend	Cat# 100212
Armenian Hamster Anti-MouseTCRb Clone: H57–597	Biolegend	Cat# 109201
Armenian Hamster Anti-MouseTCRb Clone: H57–597 PerCp/Cy5.5	Biolegend	Cat# 109227
Donkey Anti-Rabbit, AF488 conjugated secondary	Jackson ImmunoReseach	Cat# 711-545-152
Donkey Anti-Rabbit AF546, conjugated secondary	Jackson ImmunoReseach	Cat# 711-165-152
Donkey Anti-Rabbit AF647, conjugated secondary	Jackson ImmunoReseach	Cat# 711-605-152
Donkey Anti-Guinea pig AF488, conjugated secondary	Jackson ImmunoReseach	Cat# 706-545-148
Donkey Anti-Guinea pig RRX conjugated secondary	Jackson ImmunoReseach	Cat# 706-295-148
Donkey Anti-Guinea pig AF647, conjugated secondary	Jackson ImmunoReseach	Cat# 706-605-148
Donkey Anti-Rat AF488, conjugated secondary	Jackson ImmunoReseach	Cat# 712-545-150
Donkey Anti-Rat RRX, conjugated secondary	Jackson ImmunoReseach	Cat# 712-295-150
Donkey Anti-Rat AF647, conjugated secondary	Jackson ImmunoReseach	Cat# 712-605-150
Anti-Mouse Ly6c-FITC Clone: HK1.4	Biolegend	Cat# 128005
Anti-Mouse Ly6g-PE Clone:1A8	Biolegend	Cat# 127607
Anti-Mouse CD11c-PECy7 Clone: N418	Biolegend	Cat# 117317
Anti-Mouse CD11b-PacBlue Clone: M1/70	Biolegend	Cat# 101223
Anti-Mouse 1-A/1-E-AF700 Clone:M5/114.15.2	Biolegend	Cat# 107621
Anti-Mouse CD45-AF750 Clone: 30-F11	Biolegend	Cat# 103153
Anti-Mouse CD64-PerCP-Cy5 Clone:X54-5/7.1	Biolegend	Cat# 139307
Anti-Mouse CD34 eFluor 660 Clone: RAM34	eBiosciences	Cat# 50-0341-82
Anti-mouse Ly-6A/E (Sca-1) PerCP-Cy5.5	eBiosciences	Cat# 45-5981-82
Anti-Human CD49f (α6-integrin) PE	BD Pharmingen	Cat# 555736
Chemicals, Peptides, and Recombinant Proteins
OCT Compount Tissue Tek	VWR	Cat# 25608-930
4′6′-diamidino-2-phenylindole (DAPI)	Sigma-Aldrich	Cat# 28718-90-3
Prolong Gold	Invitrogen	Cat# P36930
Ammonium Thiocyanate	Sigma-Aldrich	Cat# 221988
Glutaraldehyde Solution	Sigma-Aldrich	Cat# G5882
16% Paraformaldehyde Solution	Electron Microscopy Sciences	Cat#15700
Osmium Tetroxide	Sigma-Aldrich	Cat# 20816-12-0
Mitomycin-C	Sigma-Aldrich	Cat# M7949
Trypan Blue	Sigma-Aldrich	Cat# T8154
Rhodamine B	Sigma-Aldrich	Cat # R6626
Recombinant Murine Interlukin-6	R&D	Cat# 406-ML-CF
TRI Reagent	Sigma	Cat# T3934
Poly-L-lysine	Sigma-Aldrich	Cat# P4707
Bovine Serum Albumin	Sigma-Aldrich	Cat# A7906
Fibronectin Human Protein, Plasma	Millipore	Cat# FC010
Corning Collagen I, Rat Taile	Corning	Cat# 354236
Matrigel Matrix (Phenol Free)	Corning	Cat# 356237
E-Media	Fuchs Lab	N/A
Trypsin-EDTA(25%)	Gibco	Cat# 25200056
RPMI with L-glutamine	ThermoFisher	Cat# 11875-093
Sodium Pyruvate (100mM)	ThermoFisher	Cat# 11360070
Acid free HEPES (1M)	ThermoFisher	Cat# 15630080
Liberase™ TL Research Grade	Sigma-Aldrich	Cat# 5401020001
DNAse 1 from bovine pancreas	Sigma-Aldrich	Cat# D4263
LIVE/DEAD Fixable Blue Dead Cell Stain Kit	ThermoFisher	Cat# L23105
SYBR Green PCR Master Mix	Appliedbiosystems	Cat# 4367659
Critical Commercial Assays
Click-IT EdU Alexa-Flour Imaging Kit	Life Technologies	Cat# C10337
Directzol™ RNA MiniPrep	Zymo	Cat# R2050
TrueSeq RNA Library PrepKit	lllumina	Cat# RS-122-2001
SuperScript VILO cDNA Synthesis Kit and Master Mix	ThermoFisher	Cat# 11752050
Deposited Data
Raw RNA-seq data files NCBI Gene Expression	This paper	GSE74283
Experimental Models: Cell Lines
J2 fibroblast feeder cells	Fuchs Lab	N/A
Primary Mouse Keratinocyte Cell Lines	Fuchs Lab	N/A
Experimental Models: Organisms/Strains
C57BL6 Mice	Jackson Laboratories	JAX: 000664
Aged C57BL6 Mice	NIA
K14Cre	Fuchs Lab	N/A
Stat3fl/fl	Jackson Laboratories	JAX:016923
FVB/NJ	Jackson Laboratories	JAX:001800
FVB/NTac	Taconic Biosciences	N/A
Non/ShiLtj	Jackson Laboratories	JAX:002423
Recombinant DNA
pLKO.1 TRC Cloning Vector	Moffat et al 2006	Addgene# 10878
TRC Mouse Genome shRNA Library	Dharmacon	Cat# RMM4013
Sequence-Based Reagents: See Supplemental Table 7
Software and Algorithms
Fiji (ImageJ)	https://fiji.sc/	N/A
Adobe Photoshop and Illustrator CS5	Adobe.com	N/A
R	https://www.r-project.org/	N/A
Bowtie2	Trapnell et. al 2012, Trapnel et. al., 2010	http://bowtie-bio.sourceforge.net/bowtie2/index.shtml
CummeRbund package in R	http://compbio.mit.edu/cummeRbund/	N/A
Cufflinks	Trapnell et. al 2012, Trapnell et. al., 2010	http://cole-trapnell-lab.github.io/cufflinks/
Gene Set Enrichment Analysis (GSEA)	Tamayo, et al. 2005, Mootha, Lindgren, et al. 2003	http://software.broadinstitute.org/gsea/index.jsp
MEME software suite (including TomTom)	Bailey TL et al. 2009	http://meme-suite.org/doc/cite.html?man_type=web
FACS Diva software	BD Biosciences	N/A
FlowJo Software	FlowJo	N/A
Prism	Graphpad	N/A
Other
Sterile 1.5mm, 2mm, 4mm and 6mm Biopsy punch (Miltex)	Integra	Cat# 33-31A, 33-31, 33-34, 33-36
Spectrum Tissue Pulverizer	Fisher Scientific	Cat# 189476