Figure 2.

Notch gene signaling pathway interactions. The Notch signaling pathway network was significantly differentially activated in hair follicle root sheaths compared with basal cell carcinomas. Genes and gene sets identified as significantly differentially expressed by microarray are presented with a dark background. JAG, jagged; LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; TACE, tumor necrosis factor-ACa disintegrin and metalloproteinase metalloprotease converting enzyme; DVL2, dishevelled2; NUMB, NUMB endocytic adaptor protein; PSEN, presenilin; NCSTN, nicastrin; APH, acylaminoacyl-peptide hydrolase; MAPK, mitogen-activated protein kinase; NCID, Notch intracellular cytoplasmic domain; MAML, mastermind-like protein; HAT, histone acetyltransferase; SKIP, Ski-interacting protein; RBP-J, Recombining binding protein suppressor of Hairless; SMRT, Silencing Mediator for Retinoic acid and Thyroid hormone receptor; CtBP, C-terminal binding protein; CIR, CBF1 interacting corepressor; HDAC, histone deacetylase; HES, hairy and enhancer of split.