Figure 3.

NOTCH1, JAG2, DVL2 and HES7 expression in the normal non-follicular epithelium, hair follicle root sheaths and basal cell carcinomas. Immunohistology was conducted to define the expression of NOTCH1, JAG2, DVL2 and HES7 in pathology specimens of normal non-scalp skin, normal scalp/terminal HF biopsies, and BCCs. All of the primary antibodies exhibited a greater intensity of labeling in terminal HFs compared with nodular BCCs and non-scalp skin when tissues were processed in parallel. Scale bar, 100 µm (except D, H, L and P, where the scale bar is 40 µm). JAG2, Jagged2; DVL2, Dishevelled2; HES7, hairy and enhancer of split 7; HF, hair follicle; BCCs, basal cell carcinomas.