Figure 3.

LATS1 inhibits proliferation and invasion of cervical cancer cells. (A) MTT assay demonstrated that LATS1 transfection significantly reduced cell proliferation in the SiHa cell line (*P<0.05 vs. empty plasmid control), while LATS1 knockdown significantly increased cell proliferation in the Caski cell line (*P<0.05 vs. negative siRNA control). (B) Matrigel invasion assay demonstrated that LATS1 transfection in SiHa cells significantly decreased the number of invading cells (*P<0.05 vs. empty plasmid control), while LATS1 knockdown in Caski cells significantly increased the invasiveness of Caski cells (*P<0.05 vs. negative siRNA control). LATS1, large tumor suppressor kinase 1; siRNA, small interfering RNA.