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Suppression effect of TRIM3 on the secretion of cytokines from RA FLS. Results of ELISA assays following infection of pLVX-puro or pLVX-puro-TRIM3 lentivirus into RA FLS cells. Levels of (A) IL-1β, (B) IL-6 and (C) TNF-α were significantly suppressed at 48 h after pLVX-puro-TRIM3 viral transduction. ***P<0.001. TRIM3, tripartite motif-containing protein 3; RA, rheumatoid arthritis; FLS, fibroblast-like synoviocytes; IL, interleukin; TNF-α, tumor necrosis factor-α.
