Table 2.

Immunohistochemical analyses of lobular hepatic stellate cells / myofibroblasts markers.

	Healthy liver	Stage of fibrosis 0	Stage of fibrosis 1	Stage of fibrosis 3	Stage of fibrosis 4	P-value°
Reelin-positive lobular HSCs/MFs	2.7(1.3-3.8)	3.7(2.6-6.6)	4.7(4.7-6.8)*	9.2 (6.2-10.1)* # ^	7.6 (4.0-8.2)*	0.006
CRBP-1-positive lobular HSCs/MFs	3.4(2.4-4.9)	5.5(3.2-9.7)	6.3(5.7-8.3)*	10.1 (7.1-12.8)* ^	7.6 (4.1-10.1)*	0.022
Alpha SMA-positive lobular HSCs/MFs	9(5.6-10.2)	10(8.5-32.6)	12.6(11.9-13.9)**	13 (6.5-23.7)	23 (4.3-50.5)**§	0.003

Variables are expressed as median and 95% confidence interval (95% CI)

° P-value obtained by Kruscall Wallis test.

*P<0.05 vs healthy liver

#P<0.05 vs stage 0

^P<0.05 vs stage 1

**P<0.01 vs healthy liver

^§P<0.01 vs stage 1, obtained by Mann Whitney Test.