Fig. 6. Example of a putative polyketide alkaloid biosynthetic gene cluster identified in Streptomyces sp. NRRL-B24891. Based on the predicted structure of the chain assembled by the PKS and the presence of two genes encoding homologs of the StzE and StzF enzymes, the cluster is hypothesized to direct the biosynthesis of latumcidin 1, streptazolin 5 or a structurally-related metabolite.
