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. 2015 May 14;2:74–81. doi: 10.1016/j.bonr.2015.05.003

Table 1.

Blood levels of immunosuppressants.

Time after administration Immunosuppressant dose
CsA
2 mg/kg/day		 FK-506
0.10 mg/kg/day		 RAPA
0.05 mg/kg/day
2 h 550 ± 47 ng/ml Undetectable Undetectable
24 h 200 ± 23 ng/ml Undetectable Undetectable



Time after administration Immunosuppressant dose
CsA
2 mg/kg/day		 FK-506
3 mg/kg/day		 RAPA
1.25 mg/kg/day
2 h 670 ± 50 ng/ml 19 ± 2 ng/ml 10 ± 1.5 ng/ml
24 h 153 ± 20 ng/ml 4 ± 0.6 ng/ml 4 ± 1.4 ng/ml

Blood levels of immunosuppressants after the daily administration of the indicated doses of cyclosporine (CsA), tacrolimus (FK-506) and rapamycin (RAPA) during 3 months to five-month-old male Wistar rats (n = 3 rats/group).