Table 3.
Results of the bending test carried out in the femur of the rats treated with CsA, FK-506 and RAPA.
| SHAM | CsA | FK-506 | RAPA | ||
|---|---|---|---|---|---|
| Extrinsic properties (structural) | |||||
| Ultimate load, N | Fult | 186 ± 14 | 178 ± 10 | 158 ± 15a,b,c | 172 ± 16 |
| Ultimate displacement, mm | δult | 0.69 ± 0.14 | 0.79 ± 0.07a | 0.61 ± 0.14b,c | 0.77 ± 0.06 |
| Work to failure, mJ | U | 75 ± 20 | 90 ± 17a | 61 ± 15a,b,c | 83 ± 13 |
| Intrinsic properties (material) | |||||
| Ultimate stress, MPa | σult | 164 ± 19 | 156 ± 25 | 155 ± 12 | 150 ± 10a |
| Ultimate strain | Ɛult | 0.06 ± 0.01 | 0.08 ± 0.01a | 0.05 ± 0.01b,c | 0.07 ± 0.01 |
| Toughness, MPa | u | 6.3 ± 1.6 | 7.5 ± 1.5 | 5.4 ± 1.2b,c | 6.8 ± 0.9 |
Results of the bending test applied to the femur of five-month-old male Wistar rats treated with cyclosporine (CsA, 2 mg/kg/day), FK-506 (0.1 mg/kg/da) and rapamycin (RAPA, 0.05 mg/kg/day) during three months. Statistical significance: Mann–Whitney test; p < 0.05; a vs. SHAM, b vs. cyclosporine, c vs. RAPA.