Table 2.

Effect of intervention with vitamin D supplementation^a s-P1NP and s-CTX, s-25(OH)D₃, p-PTH, s-calcium and s-phosphate.

	Baselineb	After 16 weeksb	Difference in change (95% CI)b compared to placebo	P values
Serum 25(OHD) (nmol/L)
Intervention (n = 143)	28.7 (18.6)	48.8 (19.6)	21.3 (16.7, 26.0)	< 0.0001
Placebo (n = 71)	29.2 (15.6)	27.5 (13.7)
Serum calcium (mmol/L)
Intervention (n = 143)	2.4 (0.10)	2.37 (0.1)	− 0.005 (− 0.03, 0.02)	0.7
Placebo (n = 71)	2.4 (0.09)	2.36 (0.1)
Serum corrected calcium (mmol/L)c
Intervention (n = 143)	2.36 (0.08)	2.34 (0.1)	− 0.007 (− 0.03, 0.02)	0.5
Placebo (n = 71)	2.35 (0.1)	2.34 (0.09)
Serum phosphate (mmol/L)
Intervention (n = 143)	1.14 (0.15)	1.15 (0.16)	0.01 (− 0.03, 0.05)	0.5
Placebo (n = 71)	1.15 (0.14)	1.14 (0.16)
Plasma PTH (pmol/L)
Intervention (n = 140)	7.4 (3.7)	6.1 (2.3)	− 1.97 (− 2.7, − 1.3)	< 0.0001
Placebo (n = 69)	8.1 (4.0)	8.2 (3.9)
Bone turnover markers
Serum P1NP (μg/L)
Intervention (n = 143)	47.9 (22)	46.9 (23)	− 1.2 (− 5.4, 2.9)	0.6
Placebo (n = 71)	44.8 (16)	45.3 (25)
Serum CTX-1 (μg/L)
Intervention (n = 143)	0.19 (0.11)	0.20 (0.1)	− 0.005 (− 0.03, 0.02)	0.7
Placebo (n = 71)	0.19 (0.1)	0.20 (0.1)

^aCombined 10 and 25 μg doses.

^bAdjusted for baseline values.

^cCorrected for serum albumin.