1.
Distribution of the clinical variables according to theALDH2 genotype,n (%)
| Item | ALDH2*2/*2 | ALDH2*1/*2 | ALDH2*1/*1 | P† | P‡ |
| †P for variables was calculated using Chi-squared test.‡P for variables was calculated using multivariate ordinal logistic regression after adjusting for covariates, including gender, age, area and group.ALDH2: acetaldehyde dehydrogenase-2; HIA: high-incidence area; LIA: low-incidence area. | |||||
| Gender | 0.386 | 0.387 | |||
| Male | 69 (1.7) | 967 (24.5) | 2911 (73.8) | ||
| Female | 50 (2.1) | 617 (25.6) | 1747 (72.4) | ||
| Age, years | 0.852 | 0.989 | |||
| ≤ 60 | 82 (1.8) | 1116 (25.1) | 3250 (73.1) | ||
| >60 | 37 (1.9) | 468 (24.5) | 1408 (73.6) | ||
| Area | < 0.001 | < 0.001 | |||
| HIA | 55 (1.7) | 735 (22.8) | 2429 (75.5) | ||
| LIA | 64 (2.0) | 849 (27.0) | 2229 (70.9) | ||
| Group | 0.272 | 0.277 | |||
| Case | 48 (1.8) | 643 (23.9) | 1995 (74.3) | ||
| Control | 71 (1.9) | 941 (25.6) | 2663 (72.5) | ||