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Bidirectional effects of Rap1 signaling in different tumor types
| Item | Metastasis-promoting tumor | Metastasis-suppressing tumor |
| HNSCC: head and neck squamous cell carcinoma; SCC: squamous cell carcinoma. | ||
| Rap1 | Breast, esophageal, glioma, HNSCC, leukemia, lung, melanoma, pancreas, prostate, ovarian | Bladder, glioma, lung, prostate |
| GEFs | Colon, pancreas, ovarian | Breast, osteosarcoma |
| GAPs | Breast, leukemia, melanoma, prostate, oropharyngeal SCC | Colon, kidney, melanoma, pancreas, thyroid |
