Table 3.
Characteristics of patients enrolled in the prospective cohort component of MUSIC OS-APa.
| Untreated patients (N = 301) | Treated patients |
|||
|---|---|---|---|---|
| New users (N = 1416) | Experienced users (N = 1871) | All patients (N = 3287) | ||
| Age, mean (SD) years | 63.0 (9.3) | 62.9 (9.5) | 67.3 (9.0) | 65.4 (9.5) |
| Age at menopause, mean (SD) yearsb | 48.5 (4.8) | 47.2 (5.6) | 48.4 (5.1) | 47.9 (5.4) |
| Race, n (%)c | ||||
| Caucasian | 36 (12%) | 80 (6%) | 374 (20%) | 454 (14%) |
| East Asian | 97 (32%) | 372 (26%) | 1107 (59%) | 1479 (45%) |
| West Asians | 167 (56%) | 963 (68%) | 389 (21%) | 1352 (41%) |
| Other | 0 (0%) | 1 (0%) | 0 (0%) | 1 (0%) |
| Height, mean (SD) cm | 154.7 (6.4) | 153.6 (6.9) | 154.5 (6.6) | 154.1 (6.7) |
| Weight, mean (SD) kg | 62.6 (12.5) | 60.9 (11.8) | 57.8 (10.9) | 59.1 (11.4) |
| Highest level of education, n (%) | ||||
| High school or less | 203 (68%) | 1067 (75%) | 1333 (71%) | 2400 (73%) |
| Non-university certificate or diploma | 16 (5%) | 47 (3%) | 92 (5%) | 139 (4%) |
| University degree or higher | 73 (24%) | 240 (17%) | 347 (19%) | 587 (18%) |
| Prefer not to answer | 8 (3%) | 62 (4%) | 98 (5%) | 160 (5%) |
| Physical exercise, mean (SD) hours/week | 4.0 (4.1) | 3.1 (4.7) | 4.6 (5.3) | 4.0 (5.1) |
| Hypothyroidism, n (%) | 67 (22%) | 204 (14%) | 230 (12%) | 434 (13%) |
| Mean FRAX score (SD)d | 5.8 (5.4) | 10.6 (11.1) | 15.5 (13.7) | 12.8 (12.5) |
| OP risk factors, n (%) | ||||
| Alcohol use (≥ 3 units per day) | 2 (1%) | 5 (0%) | 10 (1%) | 15 (0%) |
| Current smoking | 4 (1%) | 14 (1%) | 21 (1%) | 35 (1%) |
| Glucocorticoid use | 10 (3%) | 36 (3%) | 78 (4%) | 114 (3%) |
| Parental hip fracture | 18 (6%) | 42 (3%) | 140 (7%) | 182 (6%) |
| Prior OP fractures | 53 (18%) | 225 (16%) | 482 (26%) | 707 (22%) |
| Rheumatoid arthritis | 27 (9%) | 103 (7%) | 167 (9%) | 270 (8%) |
| Secondary osteoporosis | 18 (6%) | 36 (3%) | 127 (7%) | 163 (5%) |
cm, centimeter; kg, kilogram; OP, osteoporosis; SD, standard deviation.
a
Two patients, one untreated and one experienced user, were excluded from this table because of missing data on GI events.
b
One experienced user and one new user had missing data.
c
Caucasian was defined as European, Mediterranean, Middle Eastern, or North African Descent. East Asian was defined as Chinese, Korean, Japanese, or Taiwanese. West Asian was defined as Indian or Pakistani. Other included only those identifying as New Zealand Maori.
d
FRAX scores were recorded for 21, 89, 72, and 161 patients in the respective columns.