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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Neuroscience. 2016 Mar 18;324:390–398. doi: 10.1016/j.neuroscience.2016.03.032

Figure 4. CD44 agonist induces mechanical hyperalgesia that is attenuated by the CD44 antagonist A5G27, and high molecular weight hyaluronan (HMWH).

Figure 4

Rats received an intradermal injection of vehicle (control, blank bar), the CD44 receptor antagonist A5G27 (1 μg, gray bar) or HMWH (1 μg, black bar) on the dorsum of the hind paw. 10 minutes later, the CD44 agonist A6 (1 μg) was injected at the same site. Mechanical nociceptive thresholds were evaluated before and 30 min after A6. While in the control group we observed intense mechanical hyperalgesia, in the groups pretreated with A5G27 or HMWH it was significantly attenuated (**** p < 0.0001, when the A5G27- and the HMWH-treated groups are compared to the control group). (One-way ANOVA followed by Bonferroni's post hoc test; n = 6 paws per group)