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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Neuroscience. 2016 Mar 18;324:390–398. doi: 10.1016/j.neuroscience.2016.03.032

Figure 6. Role of CD44 receptor in carrageenan-induced mechanical hyperalgesia.

Figure 6

Rats received an intradermal injection of vehicle (control, blank bar) and, the CD44 receptor antagonist A5G27 (1 μg, gray bar) or HMWH (1 μg, black bar) on the dorsum of the hind paw. 10 minutes later, carrageenan (1%) was injected at the same site. Mechanical nociceptive thresholds were evaluated before and 4 h after the injection of carregeenan. Significant attenuation of the hyperalgesia induced by carrageenan was observed in the groups pretreated with A5G27 or HMWH (* p = 0.021, when compared to the control groups), indicating a role for the ECM in nociceptor sensitization produced by carrageenan. (One-way ANOVA followed by Bonferroni's post hoc test; n = 6 paws per group)