Table 7.
| Sexual Function Score at hysterectomy (95% CI) |
Annualized Rate of Change in Sexual Function Score (95% CI) | Mean Change in Sexual Function Score from 2 years before to 5 years after hysterectomy (95% CI) |
||
|---|---|---|---|---|
| Segment 1: From 13 years before to date of hysterectomy |
Segment 2: From date of hysterectomy to 15 years after |
|||
|
Adjusted mean in referent groupc |
18.6 (17.3, 19.8) | −0.25 (−0.61, 0.11) | −0.25 (−0.49, −0.003) | −1.74 (−3.06, −0.43) |
| Adjusted associations of predictors with trajectory parameters | ||||
| Time-invariant predictors | ||||
| Age at FMP (years) | −0.08 (−0.21, 0.06) | −0.01 (−0.05, 0.04) | −0.008 (−0.03, 0.02) | −0.05 (−0.20, 0.09) |
| Race/ethnicity | ||||
| African-American | 1.17 (−0.16, 2.51) | 0.19 (−0.24, 0.62) | 0.16 (−0.04, 0.36) | 1.18 (0.03, 2.36) |
| Chinese | −0.25 (−3.52, 3.02) | 0.43 (−0.44, 1.31) | −0.33 (−0.78, 0.11) | −0.79 (−3.44, 1.85) |
| Japanese | 0.31 (−2.32, 2.95) | 0.77 (−0.37, 1.92) | −0.41 (−0.80, −0.01) | −0.46 (−3.18, 2.27) |
| Hispanic | −1.27 (−5.13, 2.59) | −0.06 (−1.09, 0.98) | 0.40 (−0.30, 1.11) | 1.89 (−1.82, 5.60) |
| Time-varying predictorsd | ||||
| No bilateral oophorectomy | 0.25 (−0.67, 1.16) | --- | −0.19 (−0.38, 0.01) | --- |
| Late peri / postmenopause | 0.06 (−0.98, 1.09) | 0.29 (−0.11, 0.70) | --- | --- |
| Fair/poor health | −0.53 (−1.21, 0.15) | −0.08 (−0.59, 0.42) | −0.10 (−0.35, 0.14) | −0.69 (−2.31, 0.92) |
| Not married or partnered | −0.28 (−1.02, 0.47) | −0.26 (−0.61, 0.09) | −0.10 (−0.29, 0.10) | −1.00 (−2.16, 0.16) |
| Hormone use | --- | --- | −0.09 (−0.26, 0.10) | --- |
| Putative Mechanisms: Time-varyingd | ||||
| VMS at least 6 /14 days | −0.14 (−0.59, 0.30) | −0.42 (−0.85, 0.02) | −0.01 (−0.19, 0.16) | −0.89 (−2.12, 0.33) |
| Vaginal dryness | ||||
| 1–5 days / week | −0.92 (−1.40, 0.43) | 0.19 (−0.26, 0.64) | −0.11 (−0.30, 0.08) | −0.18 (−1.49, 1.13) |
| 6–7 days / week | −1.63 (−2.28, 0.98) | −0.20 (−0.73, 0.33) | 0.25 (0.03, 0.48) | 0.87 (−0.68, 2.43) |
| Depression | −0.53 (−1.07, 0.003) | 0.33 (−0.05, 0.72) | −0.05 (−0.28, 0.18) | 0.41 (−1.00, 1.82) |
| Anxiety | 0.15 (−0.36, 0.67) | 0.16 (−0.22, 0.54) | −0.01 (−0.21, 0.20) | 0.30 (−1.00, 1.59) |
a
761 observations included in Table 7 analyses.
b
Statistically significant results (p<.05) are shown in bold
c
Referent group: Age at FMP = 51.8, white, in good or better overall health, married or partnered, not using hormones, pre or early peri at time of hysterectomy, bilateral oophorectomy, VMS less than 6 days in past 2 weeks, no vaginal dryness, no depression, no anxiety, and from Pittsburgh site.
d
For time-varying predictors, the association between change in the predictor over time and contemporaneous change in sexual function score is also given by the entries in the first column (score before hysterectomy).
P value for test of difference in slopes between segments 1 and 2 in referent group: 0.98